C.H. Boehringer Sohn AG & Ko. KG is the parent company of Boehringer Ingelheim GmbH, which was founded in 1885 by Albert Boehringer in Ingelheim am Rhein, Germany. The Boehringer Ingelheim group is one of the world's 20 leading pharmaceutical companies. Still headquartered in Ingelheim, it operates globally with 146 affiliates and more than 47,700 employees. The company's key areas of interest are: respiratory diseases, metabolism, immunology, oncology and diseases of the central nervous system. Boehringer Ingelheim is a full member of the European Federation of Pharmaceutical Industries and Associations EFPIA. The corporate logo of Boehringer Ingelheim depicts a stylized rendition of the central section of the imperial palace of Charlemagne.
Video Boehringer Ingelheim
Activities
Boehringer Ingelheim works in human pharmaceuticals, animal health, and biopharmaceuticals. The group consists of 145 affiliated companies with 50.000~ employees in 2017 in all continents. Research and development facilities were in five sites and 20 production plants in 13 countries. The research and development facilities are located in Biberach (Germany), Ridgefield (Connecticut), Vienna, Kobe, and Milan(closed in 2017). Over 8,000 employees work for Boehringer Ingelheim in research and development.
Maps Boehringer Ingelheim
Company history
In 2004 the company acquired STEAG microParts GmbH. In December of the same year the company announced the acquisition of the outstanding shares of Boehringer Ingelheim Shionogi Vetmedica.
In June 2008, the company announced its intention to acquire Actimis Pharmaceuticals for $515 million, depending on the performance of Actimis' leading asthma compound AP768.
In 2009 through its US subsidiary, Boehringer Ingelheim Vetmedica Inc., acquired a significant portion of the Fort Dodge Animal Health business from Pfizer.
In 2010 BI, through its Boehringer Ingelheim Japan Investment GK subsidiary, acquired all outstanding shares of SSP CO., Ltd, with Nippon Boehringer Ingelheim Co., Ltd already holding 60.2% of SSP CO's shares.
In August 2012 the company acquired FX125L and the somatotaxin programme from Funxional Therapeutics for an undisclosed sum.
In May 2015, the company acquired the investigational drug PXS4728A from Pharmaxis'. In July, the company sold its Roxane business to Hikma Pharmaceuticals Plc for $2.65 billion ($1.18 billion in cash and issue 40 million new Hikma shares). The company also agreed to make cash payments of up to $125 million based on performance milestones. On the same day the company announced it would partner with Hanmi Pharmaceutical to develop and commercialise HM61713, a third generation treatment for EGFR mutation-positive lung cancer. Boehringer also terminated its collaboration with Vitae Pharmaceuticals on a new BACE program for Alzheimer's.
The company sold the rights to Faldaprevir, a HCV protease inhibitor to Trek Therapeutics.
In July 2016 the company sold the commercialisation rights to BI 655066, to AbbVie for $595 million upfront as well as undisclosed milestone payments and royalties. BI 655066 is a drug in late-stage testing for psoriasis, and in earlier testing for Crohn's disease, psoriatic arthritis and asthma. In September of the same year the company announced it would acquire ViraTherapeutics for EUR210 million ($230 million), a developer of oncolytic virus therapies, dependant on the success of Phase I trials.
2016 - Sanofi asset swap
In June 2016, the company announced it had struck an asset-swap deal with Sanofi, Boehringer would sell its consumer health division (valuing it at EUR6.7 billion) and EUR4.7 billion in cash, whilst acquiring the Merial animal health division (valuing it at EUR11.4 billion / $12.4 billion). The deal could mean that Boehringer is now one of the animal healthcare global leaders. In September of the same year, Amgen announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of multiple myeloma. As part of the asset swap, Boehringer and Merial sold a number of assets to Ceva Santé Animale - namely some animal health vaccines and pharmaceuticals from the Merial portfolio for swine, bovine and companion animals, as well as some intellectual property, manufacturing processes and R&D activities. In October 2016 the company sold its US pet vaccines business and a manufacturing plant for $885 million, to Eli Lilly Cos Elanco Animal Health division.
Timeline
- 1885: Albert Boehringer buys a small tartar factory in Ingelheim am Rhein; work begins on 1 August.
- 1886: The factory commences production of tartaric acid for use in the food industry (e.g. in baking powder and carbonated beverages).
- 1893: Albert Boehringer renames the company C. H. Boehringer Sohn (CHBS) after his father, Christoph Heinrich Boehringer.
- 1893: While experimenting with the production of citric acid, lactic acid is formed. Albert Boehringer develops this process, with the intention of producing lactic acid on a larger scale.
- 1895: Lactic acid is produced on an industrial scale, and is successful commercially.
- 1917: Professor Heinrich Wieland, chemist, future Nobel Prize winner and cousin of Albert Boehringer, sets up the company's research department.
- 1928: Albert Boehringer purchases Dr. Karl Thomae, a company based in Winnenden near Stuttgart.
- 1946: Dr. Karl Thomae GmbH is re-opened in Biberach an der Riss with a staff of 70 people.
- 1954: The company hires former Nazi Fritz Fischer after he is released from jail. Fischer was convicted of war crimes and crimes against humanity at the Nuremberg Trials.
- 1955: The Animal Health division is established as the company acquires Pfizer's veterinary programme.
- 1971: The foreign subsidiary, Boehringer Ingelheim Pharmaceuticals, Inc is founded in Ridgefield, Connecticut (USA). This site is soon expanded, and becomes the company's North American research centre.
- 1985: The Institute for Molecular Pathology (IMP) is established in Vienna; it opens in 1988.
- 1986: The biotechnological centre in Biberach begins production of biopharmaceuticals from cell cultures.
- 1998: The merging of Boehringer Ingelheim KG and Dr. Karl Thomae GmbH founds Boehringer Ingelheim Pharma KG.
Collaborative research
Boehringer Ingelheim is involved in publicly funded collaborative research projects with other industrial and academic partners. One example in the area of non-clinical safety assessment is the InnoMed PredTox. The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiative of EFPIA and the European Commission.
Operational/development sites
Boehringer Ingelheim is a globally operating company, with 146 subsidiaries around the globe. The company's largest site and corporate headquarters is in Ingelheim am Rhein near Mainz and Frankfurt, Germany. Their main business regions are Europe, North America and Asia. The Research Institute of Molecular Pathology[5] in Vienna (Austria), founded in 1985, has had Boehringer Ingelheim as its main sponsor since 1993.
Closure of drug manufacturing plant
In 2011 Ben Venue Laboratories in Bedford, Ohio, a division of Boehringer Ingelheim, voluntarily shut down after a U.S. Food and Drug Administration inspectors' report that found the plant had rusty tools, mold, and a barrel of 'unknown liquid', later found to be urine. The company invested US$300,000,000 to upgrade the drug manufacturing plant, and limited production resumed in October 2012. However, on 3 October 2013, Ben Venue announced that it would be ceasing production by the end of 2013 due to being unable to "return to sustainable production."
Key product lines
Prescription Medicines:
- Actilyse (alteplase)
- Aggrenox (dipyridamole / acetylsalicylic acid)
- Alna / Flomax (tamsulosin)
- Aptivus (tipranavir)
- Berodual (ipratropium bromide / fenoterol)
- Combivent (ipratropium bromide / salbutamol)
- Gilotrif / Giotrif (afatinib)
- Jardiance (empagliflozin)
- Jentadueto / TrajentaDuo (linagliptin / metformin)
- Metalyse (tenecteplase)
- Micardis (telmisartan)
- Micardis Plus / Micardis HCT (telmisartan / hydrochlorothiazide)
- Mirapex / Sifrol (pramipexole)
- Mobic / Movalis (meloxicam)
- Pradaxa (dabigatran etexilate)
- Spiriva (tiotropium bromide)
- Trajenta / Tradjenta (linagliptin)
- Twynsta (telmisartan / amlodipine)
- Viramune (nevirapine)
Consumer Health Care:
- Antistax (red vine leaf extract)
- Bisolvon (bromhexine)
- Buscopan / Buscapina (hyoscine butylbromide)
- Dulcolax (bisacodyl)
- Zantac (ranitidine)--75 and 150 mg tablets; 300 mg tablets, syrup and solution for injection are manufactured by GlaxoSmithKline
- Mucoangin / Mucosolvan (ambroxol)
- Pharmaton (standardized ginseng extract, vitamins, minerals, trace elements)
- Silomat(dextromethorphan)
- Thomapyrin (acetylsalicylic acid, paracetamol, caffeine)
Animal Health:
- CircoFLEX (porcine circovirus vaccine type 2, killed Baculovirus vector)
- Duramune (a line of pet vaccines)
- Metacam (meloxicam)
- MycoFLEX (Mycoplasma hyopneumoniae bacterin)
- Vetmedin (pimobendan)
- Pexion (imepitoin)
Product pipeline
Boehringer Ingelheim's product pipeline targets lung disease, cancer, and hepatitis C.
Litigation
In October 2012 Boehringer Ingelheim settled a "qui tam" (whistleblower) case with the U.S. government for $95 million alleging "off-label" marketing of the drugs Aggrenox, Atrovent, Combivent, and Micardis for uses that weren't approved by the US Food and Drug Administration and were not covered by federal health care programs.
In August 2012, Pradaxa claims filed in the federal court were consolidated in a multi-district litigation in the Southern District of Illinois before Chief Judge David R. Herndon. On 28 May 2014, a $650 million settlement was announced on behalf of approximately 3,900 claimants who were injured by the drug Pradaxa made by Boehringer Ingelheim Pharmaceuticals, Inc. The drug is alleged to cause severe bleeding events and/or hemorrhaging to those who were taking the drug.
In popular culture
The Company is mentioned as being a former place of work for one of the Characters in Season Two, Episode Ten, of the Scandinavian Police thriller Series, The Bridge (Danish/Swedish TV series).
See also
- Robert Boehringer
References
External links
- Boehringer Ingelheim Corporate website
- Documents and clippings about Boehringer Ingelheim in the 20th Century Press Archives of the German National Library of Economics (ZBW).
Source of the article : Wikipedia
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